Conditions treated with Niraparix
Maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy.
Where Niraparix fits
Niraparix is a maintenance therapy — it is used to keep a recurrent cancer under control after it has responded to platinum-based chemotherapy.
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1
Recurrent cancer
Ovarian, fallopian tube or primary peritoneal cancer returns.
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2
Platinum chemotherapy
Patient receives a platinum-based regimen.
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3
Complete or partial response
The cancer responds to chemotherapy.
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4
Start Niraparix
No later than 8 weeks after the last platinum regimen.
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5
Continue daily
Until disease progression or unacceptable toxicity.
Epithelial Ovarian Cancer
Epithelial ovarian cancer starts in the cells that cover the outer surface of the ovary and is the most common type of ovarian cancer.
Early symptoms — such as bloating, pelvic or abdominal pain, feeling full quickly and urinary urgency — are often vague, so many cases are diagnosed at an advanced stage. Even after a good response to surgery and chemotherapy, the disease frequently comes back.
- Starts in the surface cells of the ovary
- Most common form of ovarian cancer
- Recurrence is common after first-line treatment
Role of therapyFor adults with recurrent disease who are in a complete or partial response to platinum-based chemotherapy: Niraparix 300 mg once daily as maintenance treatment.
Fallopian Tube Cancer
Fallopian tube cancer begins in the tubes that carry eggs from the ovaries to the uterus. Primary fallopian tube cancer was once considered rare, but many high-grade serous cancers previously thought to start in the ovary are now believed to originate in the fallopian tube.
Because it shares its biology, behaviour and treatment approach with epithelial ovarian cancer, it is managed in the same way — including maintenance therapy after response to platinum-based chemotherapy.
- Begins in the fallopian tube lining
- Closely related to high-grade serous ovarian cancer
- Managed like epithelial ovarian cancer
Role of therapyFor adults with recurrent disease who are in a complete or partial response to platinum-based chemotherapy: Niraparix 300 mg once daily as maintenance treatment.
Primary Peritoneal Cancer
Primary peritoneal cancer develops in the peritoneum — the thin layer of tissue that lines the abdomen and covers the organs inside it.
Its cells look and behave much like epithelial ovarian cancer cells, and it can occur even in people whose ovaries have been removed. It is staged and treated in the same way as epithelial ovarian cancer.
- Arises in the abdominal lining (peritoneum)
- Cells resemble epithelial ovarian cancer
- Same treatment approach as ovarian cancer
Role of therapyFor adults with recurrent disease who are in a complete or partial response to platinum-based chemotherapy: Niraparix 300 mg once daily as maintenance treatment.
This information is educational and does not replace medical advice. Treatment decisions should be made by the treating oncologist based on the full prescribing information.
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